Abstract
Objective: To evaluate the efficiency of venous thrombolysis on acute ischemic stroke patients within the first 4.5 hours and adverse effects of the therapy. Subjects and Methods: A case series longitudinal descriptive study in 51 acute ischemic stroke patients within the first 4.5 hours, who are eligible for venous thrombolysis (based on ASA guideline) at Military hospital 175 from 9/2019 to 9/2020. Results: NIHSS reduces after 24 hours from thrombolysis administration, which has statistical significance (p<0,001). Patients who have good outcome (mRs 0-1) at 7 days and 3 months account for 43.2% and 68.7%, respectively. 13 cases have hemorrhagic transformation: 6 have new symptoms and 7 have no new symptoms. 3 cases with mild bleeding from other areas (bleeding gums, hematuria). Conclusion: Thrombolytic therapy in acute ischemic stroke within the first 4.5 hours has neurological recovery effect, recorded adverse effects rates are similar to other studies
