Tóm tắt
Objectives: To describe the clinical, electroencephalographic (EEG) and magnetic resonance imaging (MRI) characteristics of patients with epilepsy associated with cerebral cavernous malformation (CCM), and to determine the association between MRI features and EEG abnormalities.
Methods: A retrospective cross-sectional study of the medical records of 63 consecutive patients treated at Bach Mai National Institute of Neuroscience from January 2025 to August 2026. Associations were tested with the chi-square or Fisher’s exact test.
Results: The mean age was 42.9 ± 14.9 years; 60.3% of patients were male. Focal-onset seizures accounted for 68.3%, most commonly focal to bilateral tonic–clonic seizures (36.5%). EEG was abnormal in 42.9% of patients (epileptiform discharges, 31.7%). Lesions were mainly frontal (42.9%) and temporal (34.9%), and 77.8% of patients had a single lesion. EEG abnormality was associated with lesion lobe (p=0.024) and relation to the cortex (p=0.023), and was most frequent with cortical lesions (75.0%). Patients aged ≤40 years had more EEG abnormalities (57.6% vs. 26.7%; p=0.013) and more cortical lesions (30.3% vs. 6.7%; p=0.002) than older patients.
Conclusion: In CCM-related epilepsy, focal-onset seizures predominate, and routine EEG abnormalities are associated with lesion location, particularly cortical involvement.
