Abstract
Progressive supranuclear palsy (PSP) is the most common neurodegenerative disorder among atypical parkinsonian syndromes. It is clinically characterized by vertical supranuclear gaze palsy, postural instability with recurrent unexplained falls, bradykinesia, and cognitive impairment. Neuropathologically, PSP is defined by the abnormal accumulation of tau protein and is classified as a primary tauopathy. Early recognition of its clinical features and underlying pathology is essential for accurate diagnosis, differential diagnosis, and patient management.